Moderator is an Adobe Air application that allows you to peek into your WordPress blog and manage any comments that are awaiting moderation.
You can see who wrote the comment, their email, Gravatar icon, what they said, when they said it, and then you can decide to accept, spam or delete the comment. The settings also allow you to set the refresh interval and hide Gravatars if you’d like.
Another nice feature is that there are dock and system tray notifications of the number of unmoderated comments.
At this time, Moderator does not allow you to do a whole lot, but they plan on adding the ability to see all comments, reply to comments, manage multiple blogs comments, and get desktop pop-up notifications of new comments.